Janet Rowley

Biography

Janet Rowley was a geneticist who discovered in 1972 that chromosomal translocations — where pieces of chromosomes swap places — can cause cancer, fundamentally changing our understanding of cancer genetics. She identified the specific translocation in the Philadelphia chromosome responsible for chronic myelogenous leukemia. Her work led directly to the development of imatinib (Gleevec), one of the first targeted cancer therapies. She received the Presidential Medal of Freedom in 2009 for her transformative contributions to medicine.

珍妮特·罗利是一位遗传学家，1972年发现染色体易位——即染色体片段互换位置——可以导致癌症，从根本上改变了人们对癌症遗传学的认识。她鉴定了慢性粒细胞白血病中费城染色体的特定易位。她的工作直接促成了伊马替尼（格列卫）的开发，这是最早的靶向癌症疗法之一。2009年，她因对医学的变革性贡献获得了总统自由勋章。

Key Achievements

• Discovered chromosomal translocations cause cancer (1972)

  发现染色体易位可导致癌症（1972年）

• Identified Philadelphia chromosome translocation in leukemia

  鉴定白血病中费城染色体的易位

• Presidential Medal of Freedom (2009)

  总统自由勋章（2009年）

References & Citations

1. Wikipedia: Janet Rowley — https://en.wikipedia.org/wiki/Janet_Rowley
2. National Medal of Science and Presidential Medal of Freedom citations.